pentobarbital raises toxicity of buprenorphine, very long-performing injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants improves danger of adverse reactions which includes overdose, respiratory despair, and Dying. Cessation of benzodiazepines or other CNS depressants is most popular usually.

pentobarbital will minimize the extent or influence of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is often a sensitive CYP3A4 substrate. Coadministration with potent or reasonable CYP3A4 inducers is contraindicated.

With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.

fentanyl intranasal and pentobarbital equally enhance sedation. Stay away from or Use Alternate Drug. Restrict use to sufferers for whom alternate treatment method choices are insufficient

pentobarbital will minimize the level or impact of irinotecan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

Contraindicated (1)pentobarbital will lower the level or influence of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

benzhydrocodone/acetaminophen and pentobarbital equally maximize sedation. Steer clear of or Use Alternate Drug. Limit use to people for whom alternate treatment method solutions are insufficient

pentobarbital will lower the level or outcome of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.

pentobarbital will reduce the extent or effect of stiripentol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. If struggling to avoid coadministration of stiripentol with solid CYP3A4 inducers, enhance stiripentol dose.

pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Warning/Watch. Drugs that increase delta-aminolevulinic acid synthetase could minimize hemin result.

pentobarbital will lower the extent or influence of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.

After stopping a CYP3A4 inducer, as the effects on the inducer drop, the fentanyl plasma focus will improve which could maximize or lengthen both of those the therapeutic and adverse effects.

Contraindicated (one)pentobarbital will lower the extent or impact of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a delicate CYP3A4 substrate. Coadministration with powerful or reasonable CYP3A4 inducers is contraindicated.

pentobarbital will lower the extent or more info result of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.